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Although a single RCT failed to observe a statistically significant improvement in HOMA-IR (85), this discrepancy is more likely attributable to limited sample sizes, restricted follow-up windows, and heterogeneity in baseline metabolic phenotypes rather than a lack of efficacy

Recovery should be measured by function, strength, resilience, and return to activity, not only by symptom reduction

In contrast, lacosamide blocks the slow inactivation state, which may explain the added benefit of lacosamide in combination with carbamazepine

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Autologous fat grafting: This procedure involves fat transfer from one body area to another, for example, from the thigh to the face