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The treatment duration limit stems from animal safety data

Hedenstierna and Larsson, 2012), to assess the degree of severity that can be treated with this therapy, higher intra-abdominal pressures of 25, 30, 40, and 50 mmHg were also used

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Selling them as a pre-mixed liquid would dramatically shorten their shelf life and make them susceptible to degradation during shipping and storage

Davis-Dusenbery BN, Wu C, Hata A