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These tetrapeptides exhibit antifungal activity akin to alpha-melanocyte-stimulating hormone (-MSH), and theoretical calculations have elucidated their biologically relevant conformation and minimal structural requirements for antifungal response, guiding future compound design

Dihexa has been proven to be stable in the blood for over 5 hours (not shown), survived passage through the gut to penetrate the blood brain barrier, and overcomes cognitive deficits in acute and chronic models of dementia (not shown)

Biochemistry 48, 76987704

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