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Several studies have found that how long B12 remains in the system can depend on underlying factors such as tendencies towards developing certain diseases and lifestyle choices

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Individual optimization: You identify your personal optimal dose

Autoimmune Aspects and Co-existing Conditions PA is one of many autoimmune diseases (e.g., alongside Type 1 diabetes, Hashimotos thyroiditis, vitiligo, or multiple sclerosis)

doi: 10.1016/j.bbrc.2004.04.199

Rather than simply continuing the dose that produced maximum weight loss, providers work with patients to find the minimum effective dose for weight maintenance