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For PTH1R 37 and GCGR 38 (whose crystal structures were determined with PGS domain fusion in ICL3 and T4L fusion at ICL2, respectively), agonist binding failed to promote the outward movement of the intracellular half of TM6 as seen in the inactive state, probably due to the fusion

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The term dermatitis is used synonymously with eczema and describes either an acute skin disease with redness, oedema and vesicles (water blisters) or a more chronic type with hyperkeratosis, fissures and scaling