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457 Activation of N-methyl-D-aspartate (NMDA) receptors amplifies and prolongs spinal dorsal horn neuron responses, further contributing to pain perception

For example, people with diabetes may be able to manage mild CKD by controlling blood sugar effectively with insulin or drugs like metformin and Jardiance

Bell ML, Kenward MG, Fairclough DL, Horton NJ

Unfortunately, a study published in JAMA, found that the use of certain diabetes or weight loss medications (i.e., GLP-1 agonists such as Ozempic, Mounjaro, Wegovy, or Rybelsus) may be associated with an increased risk of developing stomach paralysis or gastroparesis

A slower increase (0.25 mg weekly for weeks 14, then stepping up in month two) typically produces steadier, more tolerable weight loss

Patient Scenarios: Which Is Right for You