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Most of the studies reviewed have a high risk of bias (e.g., failure to blind, failure to report randomization procedures, and failure to use a placebo or sham control group) and small sample sizes
GIP is secreted by the enteroendocrine K-cells concentrated in the proximal intestines, including the duodenum and jejunum ( via both neural and endocrine mediated factors ( Incretins act on G-protein coupled receptors on the beta cells of the pancreas, leading to a cAMP mediated pathway that ultimately results in insulin secretion ( Figure 1 )
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Severe and rare side effects requiring emergency medical attention include: Pancreatitis: Inflammation of the pancreas causing severe abdominal pain
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