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What distinguishes GHK-Cu from other bioactive peptides is its dual nature as both a naturally occurring component of mammalian plasma and a precisely engineered copper delivery system

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In a mouse model of allergic rhinitis, it exerts anti-allergic effects by suppressing the Th2 response, thereby reducing IgE and histamine levels, inhibiting the TLR4/MyD88/NF-B pathway to attenuate inflammation, and promoting Th1 activation while restoring the Th1/Th2 immune balance (Li et al., 2023a