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Estrogen is an essential hormone for metabolic health, and as it declines through perimenopause and menopause, the body becomes more insulin resistant

The other gets a denial letter and a suggestion to try diet and exercise first

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It has been shown to upregulate pathways tied to collagen and glycosaminoglycan synthesis, modulate metalloproteinase (MMP) and tissue inhibitor of metalloproteinases (TIMP) balance, and support antioxidant effects, thereby contributing to matrix organization and structural stability in research settings