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One possible explanation for LHS is a persistent state of chronic low-grade inflammation in the brain or spinal cord, generated by the disease or possibly by a faulty host immune response to the virus

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To determine whether GLP-1 produced in pancreatic islets is a target for DPP-4 inhibitors, Gcg was reactivated in alpha cells of Gcg RA Null mice by crossing Gcg- null mice to PDX1Cre mice to generate Gcg RA PDX1Cre mice

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