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5.2.2 Targeting autophagy in CP-induced AKI The above observations strongly suggest the cytoprotective role of autophagy against CP-induced AKI, and because activation of autophagy by CP is not stable and is relatively retarded over the course of CP injury (Herzog et al., 2012

These pro-inflammatory mediators subsequently recruit neutrophils and monocytes to the damaged area of the liver to trigger sterile inflammation

[1] For those on oral therapy, a repeat B12 level may be checked after several months to confirm response

But there is still little clinical research in dogs, and the use in a veterinary practice is still regarded as an investigational/off-label use

It binds to copper, an essential mineral for healthy tissue, and helps increase collagen and elastin production, improve blood flow, and protect cells from damage