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In case of severe reactions such as painful swelling accompanied by rashes or other allergic symptoms, stop taking Semaglutide immediately and seek medical attention for assistance if necessary

In a smaller cohort of patients with more severe CD phenotypes, including 17% with perianal involvement and 24% with penetrating or fistulizing disease, numerical reductions across outcomes were observed in the GLP-1RA group, but these differences did not reach statistical significance (104)

Nutritional considerations play an important role in managing cold sensitivity

A pro-inflammatory diet of high-sugar, ultra-processed foods

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