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Dulaglutide was not compared to placebo in this study

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In T2D patients (n = 25, age 2565), consumption of 1 g L-citrulline twice a day for 4 weeks reduces the T2D-induced increase in arginase activity and increases plasma nitrites, effects corroborated by improvement of ACh-induced relaxation in ex vivo mouse aortic rings incubated (24-h) in low or high glucose-containing media and increases in NO production in ECs treated with high glucose (Shatanawi et al., 2020)

N Engl J Med (1992) 326(1):229

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Species differences between mouse, rat, dog, monkey and human cyp-mediated drug metabolism, inhibition and induction.Expert Opin Drug Metab Toxicol 2, 87594