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Smoking cigarettes involves a substantial amount of free radicals that may degrade exogenous and endogenous antioxidants, as well as dysregulate monocytes and vascular smooth muscle cells [70] Endothelial nitric oxide synthase (eNOS)- derived nitric oxide plays a crucial role in regulating platelet accumulation, vasodilation, and maintaining stability between smooth muscle cell growth and proliferation

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Stimulated by these encouraging results, a novel dual-action polymeric system is proposed for the potential treatment of autoimmune thyroid disease

GTPases can be divided into two main classes: (i) small monomeric GTPases and (ii) trimeric, receptor-coupled GTPases