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Owing to the extended time horizon, we rigorously applied discounting protocols specified in the Chinese Guidelines for Pharmacoeconomic Evaluations (2020 Edition) [20]: we applied a 5% annual discount rate to both costs and health outcomes

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The medication's effect on gastric emptying may influence the absorption of certain oral medications, though significant nutrient malabsorption is not a labeled effect

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By blocking opioid receptors on the POMC neurons, feedback inhibition is prevented further increasing POMC activity