Most patients experience gradual improvement as treatment continues, though some individuals may have persistent symptoms requiring management strategies or, occasionally, treatment discontinuation
A large network meta-analysis comparing weight loss and side effects found more treatment stops at the highest doses, especially due to nausea and vomiting, for both drugs, with slightly higher rates at maximum doses
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PubMed Wadden TA, Bailey TS, Billings LK, et al
Several studies found that GLP-1RAs might have direct effects on adipogenesis, lipotoxicity, fatty acid oxidation, cytokines related to hepatitis and fibrosis, and intestinal microbiota (193, 195)