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In isolation, glucagon receptor activation is associated with hepatic glucose output and lipolysis, effects traditionally viewed as counter-regulatory

Back Brown JC, Dryburgh JR, (1971) 'A gastric inhibitory polypeptide II

SURMOUNT-5, published in the New England Journal of Medicine, directly compared the maximum tolerated doses of tirzepatide and semaglutide in the same patient population

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2) GIP: metabolic support + enhanced satiety signalling GIP is part of what makes tirzepatide/Mounjaro a dual-acting medicine