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The study protocol was approved by the Tsaotun Psychiatric Center, Ministry of Health and Welfare, Taiwan

On-Treatment Analysis (If Everyone Stayed on Max Dose): CagriSema achieved 22.7% weight loss using trial-product estimand (assumes perfect adherence at max dose)

Metabolically and clinically the most detrimental effects of IR are due to disruption in insulin-mediated control of glucose and lipid homeostasis in the primary insulin-responsive tissues: liver, skeletal muscle, and adipose tissue

Supports even skin tone and clarity

doi: 10.3390/ijms221910571 8

Scicchitano BM, Rizzuto E, Musaro A: Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1