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potential effects on infant unknown Alternative : Discuss alternative weight management strategies with provider Diabetes Medication Interactions : According to FDA prescribing information, combining GLP-1 medications with certain diabetes medications increases hypoglycemia risk: High-Risk Combinations Requiring Dose Adjustments : Safe Combinations (No dose adjustment typically needed): Metformin DPP-4 inhibitors (though not recommended together due to same mechanism) SGLT2 inhibitors Thiazolidinediones Other GLP-1 Medications : Do NOT combine : Should not use two different GLP-1 medications simultaneously Mechanism overlap provides no additional benefit and increases side effect risk Other Medication Interactions : According to FDA prescribing information: Oral Medications Generally : GLP-1 medications delay gastric emptying May affect absorption of oral medications For medications requiring precise timing or levels (narrow therapeutic index drugs), consult pharmacist about timing relative to GLP-1 injection Specific Medications of Concern : Warfarin : Monitor INR more frequently when starting GLP-1 Thyroid Medications : May affect absorption

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(Click here for more background on GLP-1 medications and their use for weight loss.) How Do GLP-1 Medications Work

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Spectral counts were calculated by Scaffold software after normalization by total spectral counts of each MS run for an estimate of expression fold change between the experimental groups (29)