Its known that 22 splice variants of hTERT exist (Plyasova and Zhdanov 2021) however, only the full-length variant codes for the fully active telomerase enzyme and some variants can act in a dominant negative way to inhibit telomerase activity
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Given the inherent problems of reproductive tissue inaccessibility in healthy human subjects, we set out to identify genes associated with altered DNA methylation in buccal tissue of Bangladeshi migrant women who had grown up in Bangladesh or the UK and to compare and integrate these findings with changes in gene expression in the reproductive tissues of a suitable mouse model
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