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27 However, contrary to preclinical findings, human studies indicate that weight loss induced by GLP-1 RAs is primarily due to reduced energy intake rather than increased energy expenditure

Each of these has unique properties

Weight regain that arrives as soon as the medication stopsproof that appetite control isnt the same as metabolic correction

It's more "background enhancement" than an acute stimulant the effect builds over a cycle

Adding GIP (the tirzepatide model) deepens the effect and, somewhat counterintuitively, appears to improve gastrointestinal tolerability relative to GLP-1 alone

VAT, Visceral Adipose Tissue