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10.1016/j.heliyon.2023.e23672 28 JiangY.-H.WuS.-Y.WangZ.ZhangL.ZhangJ.LiY.et al (2022)

Active infections: NAD+ may enhance immune activity and oxidative stress, potentially worsening systemic infections or prolonging recovery

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In addition to the above benefits, glutathione is useful in modulating blood sugar in diabetics and in boosting performance in athletes

Both sources of variability will contribute to the individual susceptibility to toxicity from this widely used agent