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Limitations of RCTs presented in Table 2 and Table 3 The side effects reported at the end of a clinical trial may be partially distorted due to gastrointestinal problems if the study is stopped too early [127]

MTX-induced liver toxicity is characterized by increased levels of aminotransferases, the development of hepatic steatosis, and progression to liver fibrosis and cirrhosis

3.1 Probiotics mechanism of action Through interaction with immune cells and epithelial cells, probiotics participate in the control of immunological response ( Figure 1 )

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