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In summary, the -interaction with Phe357 and the negatively charged environment surrounding Arg358 significantly enhance the effectiveness of DPP-4 inhibitors

Antioxidants 8 , 82 (2019)

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The acetate form includes an acetate salt, which may affect formulation and stability considerations

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32 Since tirzepatide does not have a GIP (3142) tail, chosen Ala 21 was likely to increase the GLP-1 activity, despite it slightly decreasing the GIP activity