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42 , 43 Table 11: Details of Included Studies (CVOT) A1C = glycated hemoglobin

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However, a follow-up paper from the same group showed that long-term liver-specific deletion of IGF-1, as assessed in 855-week-old mice, leads to small reductions in periosteal bone growth and appendicular skeletal growth with no abnormalities in trabecular bone (Sjogren et al., 2002)

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