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The extract of Salvia przewalskii regulates immune inflammation, inhibits abnormal cell proliferation and vascular remodeling by downregulating HIF-1, PCNA, Bcl-2, CDK4, CyclinD1, P27Kip1, and inhibiting pathways such as RhoA-ROCK, MCP-1, NF-B as well as pro-inflammatory factors

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Front Immunol (2019) 10:2095

5 This may exert a profound influence on the entire organism, given the novel findings that BAs may act as hormonal signals via their interactions with several enterohepatic and peripheral target receptors