In the SURMOUNT-1 trial, patients lost an average of 22.5% of body weight over 72 weeks
Around the same time, Tirzepatide was listed as the first peptide approved for use to treat sleep apnea
Retatrutide 9 mg: mean body-weight reduction of 26.4 percent
Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials
Sanyal et al., Nat Med, 2024) has examined endpoints relevant to obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD) under controlled clinical research protocols
The effects of the leptin-GLP-1 interaction may be governed by intracellular signaling pathways, including those involving phosphorylated STAT3 and PTP1B