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43 Participants were randomised to receive subcutaneous semaglutide or placebo, and the semaglutide group had a 24% lower risk of the primary renal outcome (HR 0.76

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doi: 10.1007/s11010-017-3200-0 161 BenderskaNChakilamSHugleMIvanovskaJGandesiriMSchulze-LuhrmannJet al

4 In a parallel 36-week phase 2 obesity study, once-daily oral orforglipron produced dose-dependent weight reductions reaching a mean of about 14.7% at the top dose, with gastrointestinal effects nausea, constipation, diarrhea as the dominant, mostly mild-to-moderate adverse events, concentrated during dose escalation

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