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These osteocartilaginous outgrowths form at the joint margins at the interface of the synovium, periosteum, and articular cartilage, yet their development is tightly linked to the mechanical and molecular alterations occurring in the subchondral region (Li et al., 2013)

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Understanding B-12 Injections: What They're Used For B-12 injections, also known as cobalamin injections, are a method of administering vitamin B-12 directly into the bloodstream

Superoxide dismutase is the body's first line of enzymatic defense against intracellular free radical production through reduction of one-electron dismutation of oxygen (O 2 - ) to hydrogen peroxide (H 2 O 2 ) [10]

Gene primer sequences are shown in Supplementary Table 1