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For instance, changes in the gut microbiome have been associated with improved insulin sensitivity and increased energy expenditure, which are linked to the effects of GLP-1 on gut hormone secretion and appetite regulation

Concerns: Experimental

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Lacking any of these can harm red blood cell production

The appetite-suppressant qualities of the drug alongside slowed gastric emptying and increased metabolic efficiency are responsible for decreased calorie consumption and long-term weight loss

A runner without excess fat or adipose tissue who uses GLP-1s is likely to lose weight from the wrong places and see a decline in performance