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Animal reproductive toxicity studies conducted with GLP-1 receptor agonists as a class have raised concerns, and human data are insufficient to establish safety

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Pharmacokinetics of NNC0090-2746 showed a C max at 5.4 nM with a single dose of 1.8 mg (106) and C max at 12 nM at the steady state with a daily dose of 2 mg in patients with T2DM (107)