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Alcohol use A patient with a history of excess alcohol use must be advised to stop consuming alcohol before starting GLP-1 receptor agonist therapy

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Suspected side effects can also be reported via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk

Interestingly, certain bitter compounds, such as denatonium benzoate (DB), have been found to stimulate the secretion of insulin, glucagon, somatostatin, and GLP-1 from pancreatic islets independently of glucose levels

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That said, do not use this as justification for routinely dosing early