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Upon maturation, the proliferative HBs differentiated into functional HLCs exhibiting typical polygonal morphology and distinct round nuclei
The three-amino-acid truncation transforms IGF-1 from a highly regulated, IGFBP-bound mediator into a potent, locally-acting growth factor with minimal systemic distribution
Additionally, it serves as a signaling mechanism, influencing cellular pathways, such as cell cycle control, histone ubiquitination, and DNA repair [52]
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