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They discovered that the binding of a peptide mimicking the MDM4 C-terminus tail to MDM2 impairs MDM2-mediated ubiquitination of p53 and promotes p53-dependent transcription and oncosuppressive activities [57]
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Oral TB-500 is not a clinically valid delivery route: the peptide cannot survive the gastrointestinal tract intact in a way that produces systemic effects comparable to subcutaneous injection