More recently, the largest systematic review of studies on the association of IGF-1 with the risk of prostate cancer concluded that there is a 21% increased risk of prostate cancer per SD increase in IGF-1, with a stronger association with more aggressive and advanced cases [71]
These omega-3 FAs are also known to have anti-inflammatory effects [108,109]
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Thus, these results suggest that liraglutide could reduce, at least in part, the secretion of pro-inflammatory cytokines in OA synovium by stimulating macrophages and polarization toward an M2 anti-inflammatory phenotype, leading to a decrease in OA-induced joint destruction
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Extensive and close interactions exist between the liver and the intestine