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Results Literature Selection and Study Characteristics Among the 3055 articles obtained in the primary searches from MEDLINE, EMBASE, and CENTRAL databases and the 135 potentially relevant trials identified in ClinicalTrials.gov, a total of 28 published studies that met the inclusion criteria were included in the systematic review

This mechanism contributes to weight loss, with clinical trials of semaglutide 2.4mg (Wegovy) demonstrating average weight reductions of 1015% of body weight over 1218 months

Depression and obesity: a meta-analysis of community-based studies[J]