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In contrast, the leaf, but not root, extract inhibited the enzymatic activity of cyclooxygenase-2 (COX-2)
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Based on these results, we propose that inhibition of RNR (or upstream enzymes) leads to accumulation of GSH which can be re-purposed for use by GPX4 to prolong the inhibition of ferroptosis under conditions where new GSH synthesis is otherwise impossible (Fig 6)
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