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A plausible explanation of this apparent dichotomy is that p53 promotes cell survival by preventing excessive increases in ROS under moderate oxidative stress, whereas when the oxygen species increase over a threshold level, it switches to becoming a ROS inducer, triggering cell death
Marie Liebmann, Department of Neurology with Institute of Translational Neurology, Germany Updates Copyright 2022 Zhong, Ran, Gao, Shi, Shi, Long, Zhou, Yang, Tang, Lin, He, Yu and Han
Free Radic Res 48, 10491060
These effects are more common as you begin your treatment and usually dont arise later in your therapy