An example of where this phenomenon has been shown to occur is in the dog prostate with toenail selenium concentrations, which are a good indicator of long-term selenium status1
The first being our selection of animals slated for euthanasia for the study, which resulted in our use of several sub-strains of mice (all on a C57BL/6 background), and limited our ability to control early life experiences
Each figure here shows the residual association signal having conditioned on the index SNP of the relevant GWAS
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