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(2) EGCG induces M1 polarization via various signaling pathways including TLR4/NF-B, JAK2/STAT3, TLR2, TLR4, JNK/P38, thereby suppressing the activation of inflammatory vesicles and reducing microglial inflammation and neurotoxicity (13)

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This is consistent with evidence that odd chain and branched chain fatty acid synthesis is CrAT dependent 38 , and that isoleucine catabolism, a mitochondrial process, can supply propionyl-CoA for histone propionylation and that this correlates with production of propionyl-carnitine 8

53,153 In breast cancer and neuroblastoma, GD2 is a functional CSC marker that actively regulates tumor initiation and metastasis through the modulation of the FAK and PI3K/AKT signaling pathways

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