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Epithalon structure and discovery Chemical composition: Tetrapeptide (four amino acids) Sequence: Ala-Glu-Asp-Gly (AEDG) Also called Epitalon or Epithalone Synthetic version of epithalamin (pineal gland extract) Molecular weight: 390.35 g/mol Water-soluble peptide Discovery history: Discovered by Professor Vladimir Khavinson in St

Analysts expect the TRIUMPH-1 trial, with its longer 80-week treatment period, may show weight loss exceeding 30%, a threshold that approaches what bariatric surgery achieves

doi: 10.1016/j.aohep.2024.101774 70

Companies like Novo Nordisk and Eli Lilly are already engaging directly with employers, providing clinical value story evidence and cost-effectiveness data to support coverage decisions

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Fifth, cost-effectiveness analyses are critical given the high price of current GLP-1 RAs and the large potential treatment population: preliminary health-economic models suggest acceptable cost-effectiveness ratios in high-fibrosis patients with comorbid type 2 diabetes and cardiovascular disease, but robust data in broader MASLD populations are lacking