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202 Osteocartilagenous differentiation usually occurs in acral, particularly subungual, lesions

*Correspondence: Luo Chunyang, [email protected]

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However, not all triple GLP-1/GIP/GCG agonists are advancing to late-stage clinical trials

While the LIVE and FIGHT trials explored their effects on heart failure with reduced ejection fraction (HFrEF), the STEP-HFpEF trial demonstrated that GLP-1RAs improve HFpEF outcomes by reducing symptoms, physical limitations, and body weight [9]

Future research can focus on using specific gene knockout/knock-in animal models and combining single-cell sequencing technology to clarify the spatiotemporal expression patterns and functional differences of p53 in different cell types (such as chondrocytes, synoviocytes, and osteoclasts) and different stages of OA