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The REDEFINE Phase 3 program directly addressed this, showing CagriSema achieved 20.4% weight loss versus lesser results with semaglutide alone, cagrilintide alone, and placebo

All data are expressed as mean standard deviation

Some individuals may experience mild gastrointestinal discomfort, rashes, or allergic reactions

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Additionally, the regulation of ferroptosis can be influenced by mitochondrial tricarboxylic acid (TCA), and the inhibition of the TCA cycle in mitochondria can block the voltage-dependent channel 2/3 (VDAC2/3) to safeguard cells from ferroptosis [47]

Medical supervision is recommended