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Weight loss rate appears to be an independent variable

demonstrated that the GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant Apoe/Irs2+/ mice by promoting macrophage polarization towards an anti-inflammatory M2 phenotype, which was associated with enhanced plaque stability (i.e., thicker fibrous caps, fewer necrotic cores, and decreased inflammatory infiltrates)

Randomized trials have shown that liraglutide and semaglutide can improve walking distance in people with PAD, while observational studies have linked semaglutide and tirzepatide to lower risks of amputation, lower-extremity revascularization, and mortality

For patients comparing their options, the tirzepatide versus semaglutide dosage chart provides a direct dose-level comparison

These include those with type 2 diabetes and obesity, who depend on ozempic for their treatment