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The clinical trial data The body composition data comes from DXA substudies within the landmark registration trials for each medication

Consistent with this notion, we observed an upregulation of the required enzymatic machinery for local processing of GLP-1 including Glp1r, Pcsk1 and Dpp4 mRNAs in the OB of obese mice compared to lean mice

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doi: 10.1016/0361-9230(92)90237-r

However, given that pyridoxine is a cocatalyst of many enzymatic processes involved in amino acid metabolisms, such as racemization and decarboxylation, our results do not exclude that pyridoxine may also confer neuroprotection through other undiscovered mechanisms