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Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

In insulin-resistant conditions, BCAA catabolism is impaired, leading to accumulation and potential exacerbation of metabolic dysfunction

Most patients find that gastrointestinal symptoms improve significantly after the first 24 weeks as their body adapts to the medication

The only area where it gained some interest was as a means to help terminate hypoglycaemia in schizophrenic patients given insulin shock therapy (figure 13)

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Tirzepatide (Zepbound for weight loss, Mounjaro for diabetes), liraglutide (Saxenda), and older agents such as phentermine-topiramate (Qsymia) are also possibilities