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Karlstad O, Starup Linde J, Vestergaard P, et al

510,511 Their selectivity often involves strong hydrophobic interactions between the cap group and a large surface area on HDAC6, known as the L1 loop pocket

Stick to your planned schedule for at least two full cycles at each dose before adjusting

Switching between GLP-1 agonists may occasionally be considered for mild, localised reactions, but only under specialist supervision with appropriate monitoring