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Gastrointestinal symptoms such as abdominal pain and diarrhoea secondary to colitis are classic ipilimumab-related irAEs that manifest as loose stool, abdominal pain, haematochezia and fever

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By modulating these levels, GPx helps maintain a delicate balance, avoiding both oxidative and reductive stress

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These pathways affect significant processes linked to aging and extend beyond merely regulating glucose metabolism