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Until database lock, investigators and participants remained blinded to treatment status

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This is often called breakthrough pain

Additional experiments including a footshock-only control group demonstrated that while footshock alone induced normal fear extinction, PTSD-like mice showed significantly impaired extinction retrieval (Supplementary Fig

The primary endpoint was the incidence of CHD (defined as nonfatal MI, silent MI and CHD death), with invasive breast cancer as the primary adverse outcome

Besides A, insulin signaling disturbance also induces tau protein phosphorylation through the activation of the GSK3 enzyme pathway [151]