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GLP-1 and NMDA receptors are expressed throughout the mammalian brain and, although reports indicate that GLP-1 analogues engage central appetite circuits through distinct subpopulations of neurons (most notably in the brainstem and the hypothalamus) 36 , feedforward neural pathways modulated by inhibition of NMDA receptors specifically in GLP-1-receptor-positive neurons may differ from those engaged by exclusive activation of GLP-1 receptors

Table 2 lists the key randomized controlled trials on pharmacologic management of HFpEF

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Conversely, anti-inflammatory diets rich in fruits, vegetables, nuts, and omega-3 fatty acids were associated with fewer attacks [130]